• Regina Defrancisco is wanted for the murder of her boyfriend
  • Margaret Defrancisco is wanted for the murder of her sister's boyfriend
  • Oscar Velezquez was murdered for Money

Real Names: Regina and Margaret DeFrancisco
Aliases: None Known
Wanted For: Murder
Missing Since: June 6, 2000


Details: Regina DeFrancisco was the seventeen-year-old girlfriend of Oscar Valazquez, an honest, hardworking 22 year old Texan from Dallas who held a steady job and had just gotten a new car. Oscar was quite smitten with her and would do anything for her, but he didn't know about her violent personality. In May 2000, when Oscar received a call from Regina's 16-year-old sister Margaret asking for a large favor, he was eager to help. Margaret claimed that Regina had been wrongfully arrested and needed money to make bail, but what Oscar didn't know was that the bail money was actually for Regina's real boyfriend who was in jail. Oscar generously gave Margaret $1,000 to bail Regina out, and shortly after her boyfriend's release, she went on a date with Oscar. She promised to pay him back, and about a week later, Oscar asked Regina for the money. She said she couldn't get the money and conned him into a three-way sexual encounter with herself and Margaret.
On June 6, 2000, Oscar arrived to pick Regina up for a date and possibly begin their sexual encounter. She wasn't ready and remained upstairs, so he waited downstairs with Margaret and a friend. Then, Regina went to the basement and had Oscar follow her. Once in the cellar, Margaret came from behind and shot him in the back of the head with a semi-automatic pistol. She robbed him of over $600 and a silver necklace.
The sisters placed Oscar's body in the trunk of his new Camaro and drove to a vacant lot to dispose of his body. They poured nail polish remover over his body and set it on fire, then set his car on fire a few miles away. Oscar's mother, Maria, was worried when her son hadn't returned, and when she and her husband learned that Oscar's body may have been found, they went to the morgue to identify the body. After police questioned the sisters, they fled. Authorities believe "The Latin Kings", the street gang that the girls are affiliated with, may be helping the female psychopaths elude justice.
Extra Notes: This case first aired on the November 19, 2001 episode.
The sisters were also profiled on America’s Most Wanted and the case was later documented on Deadly Women after both was captured.

Margaret and regina defrancisco

The sisters after capture

Results: Captured. Margaret DeFrancisco was captured in March of 2002 after authorities recieved tips that she was at the home of relatives in Roscoe, Illinois. Seven months later, Regina DeFrancisco was arrested in Dallas, Texas for stealing a car from an acquaintance; she was soon discovered to be wanted in Illinois after a check of her fingerprints. Regina was found guilty of first degree murder and sentenced to 35 years in prison. Margaret's first trial ended in a mistrial, but she was found guilty at a second trial and sentenced to 46 years in prison.

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